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KMID : 0861020040190010083
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Korea Journal of Herbology
2004 Volume.19 No. 1 p.83 ~ p.88
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Study on The Effect of Styrax Benzoin on Human Epithelioid Carcinoma Cell
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Abstract
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Objective : This study was done to examine the cytotoxicity of styrax benzoin (SB) on human oral epithelioid carcinoma cell line (KI3).
Methods : The cytotoxic effect of SB was measured by MTT assay or XTT assay. The microscopic study was performed to observe the mophorlogical changes of KI3 cells.
Results : The cytotoxic effect of SB on KI3 cells showed a significant increase at 50 uM or 100 uM SB by MTT assay or XTT assay compared with control after cells were treated with various concentrations of SB for 48 hours. MTT_(50) and XTTg were 419.9 uM and 375.5 uM, respectively. In microscopic study, KB cells exposed to SB showed both the decreased cell number and the morphological changes.
Conclusion : From these results, SB has a midcytotoxicity by the showing the decrease of cell number and the morphological changes in KJ3 by MTT and XTT assays.
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KEYWORD
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